Mass Spectrometry is a powerful tool for bioreactor monitoring. Changes to the composition of bioreactor or fermenter off-gas provide crucial insight into cellular health and production efficiency. This makes the fast, accurate analysis of CO2, O2, N2, Ar, H2O and other compounds essential for real-time process control. 

The MAX300-BIO uses cutting edge quadrupole mass spectrometer technology to quantify bioreactor gases from multiple reactors within the facility and reports the data to the control system in real-time. 


  • Measures CO2, O2, N2, H2O, alcohols, contaminants, and more
  • Samples without risk of contamination
  • Calculates control parameters in real-time (e.g. Respiratory Quotient)
  • Provides flow and mass balance data
  • Multiport sample systems for up to 80+ reactors
  • High precision and accuracy for optimal process automation
  • Low maintenance, utilities and calibration required
  • Complete method scale-up
  • Lab, Pilot, Production


  • Mass Range Options:  1-250, 300, 500 amu
  • Detectable Compounds:  Any gas or vapor sample
  • Detection Range:  100% – 10 ppm standard, 10 ppb with the electron multiplier option*
  • Number of Sample Streams:  16, 31, 40 or 80+
  • Analysis Rate:  <0.4 seconds per component
  • Number of Components:  Unlimited
  • Number of Analysis Routines:  Unlimited
  • Number of User Configurable Data Tags:  Unlimited
  • Analysis Precision:  <0.25% Relative Standard Deviation**
  • Stability:  <0.5% Relative Standard Deviation over 30 days**
  • Filaments:  Two, one active and one spare with automatic switchover
  • Low maintenance:  Typically, two PMs per year
  • Manual or fully automated calibration and validation

*Matrix dependent. Documented on trace benzene in air

**Based on the analysis of 1% argon

Questions? We’re here to help.

Extrel CMS, LLC 
575 Epsilon Drive
Pittsburgh, PA 15238

Members of Process Insights, Inc.

Copyright © 2022 Process Insights, Inc.  All Rights Reserved.