Applications - Pharmaceutical / Biotechnology

Solvent Drying

Pharmaceutical manufacturers are well aware of the industry statistics that at least 25% of time and energy can be saved by terminating the active pharmaceutical ingredient drying process at its true endpoint. However, actually determining the true endpoint has always been an obstacle. To avoid interrupting the process (traditional methods to determine the drying process involved sampling and analyzing the product in a lab) and possible contamination of an entire batch, many producers choose to overextend the drying process. Today’s engineers can solve this problem by using the MAX300-IG™ Industrial Gas Analyzer or the MAX300-LG™ Laboratory Gas Analyzer. The MAX300 monitors the atmosphere composition above the drying material. Because the headspace is in close relationship with the concentration of solvents in the material, the true drying process end point can be determined by analyzing the headspace vapors. The Quadrupole Mass Spectrometer allows you the ability to view the concentration profiles of solvents over time, pinpointing the exact moment the drying is complete. In addition, each batch can be dried to the same specification, thus reducing rejection rate when the final product is tested after packaging.
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